Dopamine D1and corticotrophin-releasing hormone type-2α receptors assemble into functionally interacting complexes in living cells
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چکیده
منابع مشابه
Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes.
Recently, evidence has emerged that seven transmembrane G protein-coupled receptors may be present as homo- and heteromers in the plasma membrane. Here we describe a new molecular and functional interaction between two functionally unrelated types of G protein-coupled receptors, namely the metabotropic glutamate type 1alpha (mGlu(1alpha) receptor) and the adenosine A1 receptors in cerebellum, p...
متن کاملDopamine D1 and adenosine A1 receptors form functionally interacting heteromeric complexes.
The possible molecular basis for the previously described antagonistic interactions between adenosine A(1) receptors (A(1)R) and dopamine D(1) receptors (D(1)R) in the brain have been studied in mouse fibroblast Ltk(-) cells cotransfected with human A(1)R and D(1)R cDNAs or with human A(1)R and dopamine D(2) receptor (long-form) (D(2)R) cDNAs and in cortical neurons in culture. A(1)R and D(1)R,...
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Prolactin-releasing peptide and corticotrophin-releasing hormone R-00402-2003.R1 2 Prolactin-releasing peptide (PrRP) reduces food intake and body weight, and modifies body temperature when administered centrally in rats, suggesting a role in energy homeostasis. However, the mediators of PrRP's actions are unknown. The present study, therefore, firstly examined the possible involvement of the a...
متن کاملMetabotropic glutamate receptor type 1alpha and tubulin assemble into dynamic interacting complexes.
Metabotropic glutamate receptors (mGlu receptors) are coupled to G-protein second messenger pathways and modulate glutamate neurotransmission in the brain, where they are targeted to specific synaptic locations. Very recently, we identified tubulin as an interacting partner of the mGlu(1alpha) receptor in rat brain. Using BHK-570 cells permanently expressing the receptor we have shown that this...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2014
ISSN: 0007-1188
DOI: 10.1111/bph.12868